Acetylcholinesterase Inhibitor Activity of Some 5-Nitrothiophene-Thiazole Derivatives
نویسندگان
چکیده
The potential anticholinesterase characteristics of some thiazole derivatives (2a–2j), including the 5-nitrothiophene moiety, were examined in this work. 1H-NMR, 13C-NMR, and HRMS spectral data used to determine structure compounds. Using a modified Ellman's spectrophotometric approach, each compound was tested for its ability inhibit acetylcholinesterase (AChE) butyrylcholinesterase (BuChE) enzymes. It determined that compounds exhibited inhibition between 33.66–47.96 % against AChE 13.03–63.29 BuChE at 80 µg/mL concentration.
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ژورنال
عنوان ژورنال: Cumhuriyet Science Journal
سال: 2022
ISSN: ['2587-2680', '2587-246X']
DOI: https://doi.org/10.17776/csj.1128672